Detect Neisseria gonorrhoeae and ciprofloxacin susceptibility markers
Dual N. gonorrhoeae targets (opa & porA), gyrA S91F mutant, & gyrA S91 wildtype in a single-well multiplex qPCR test
Antibiotic resistance in gonorrhoea infections is a global concern. There are limited effective treatment options and novel antibiotics are not readily available. Smarter and more directed use of antibiotics can be achieved through Resistance Guided Therapy.
Tested on hundreds of clinical samples, ResistancePlus® GC demonstrates excellent sensitivity and specificity.
Streamline your workflow and increase productivity for rapid, routine diagnostics. Full automation options including sample and qPCR set-up, through to validated software solutions for automated result calling and simple data processing.
SpeeDx analysis software included in contract pricing is license free and installed on a high security and GDPR compliant platform:
Increase capacity of your existing qPCR instrumentation through universal run conditions compatible with all ResistancePlus® products.
Demonstrated clinical performance – for more detail please see the ResistancePlus® GC Instructions for Use.
|Performance of ResistancePlus® GC|
|GC detection||gyrA S91F Detection|
ResistancePlus® GC simultaneously detects the bacterium Neisseria gonorrhoeae (GC) and the gyrA S91 (wild type) or gyrA S91F (mutant) markers that are associated with susceptibility or resistance to the fluoroquinolone antibiotic, ciprofloxacin.
Single well: N. gonorrhoeae (Opa), N. gonorrhoeae (PorA), Ciprofloxacin resistance, Ciprofloxacin susceptibility, Internal control
Products are shipped on dry ice or ice gel packs.
Expiry dates are stated on the labels. It is recommended that freeze/thaw cycles be limited to less than 15. Store protected from light at – 20°C.
For in vitro diagnostic use. Not for sale in the USA.
CE-IVD, TGA cleared, IVDR Certified
Please contact your local representative if you can’t find what you are looking for.
We are committed to supporting continued scientific discovery and generation of clinically relevant data. Collaborations with key researchers and clinicians around the globe help us improve diagnostics and address urgent clinical needs.
Evaluation of the molecular detection of ciprofloxacin resistance in Neisseria gonorrhoeae by the ResistancePlus® assay (SpeeDx)
Samples were selected from a range of sites with corresponding cultures isolated from the same patient episode. The ResistancePlus® GC assay displayed high sensitivity for N. gonorrhoeae detection (98.5%) and gyrA detection (97.1%). There was high agreement (98.9%) between the ResistancePlus® GC assay and culture phenotype.
Reflex detection of ciprofloxacin resistance in Neisseria gonorrhoeae using the SpeeDx ResistancePlus® GC Assay
Of the concordant N. gonorrhoeae – positive samples, (86.8%) possessed gyrA S91F mutation, highly predictive of ciprofloxacin resistance. Authors confirmed Resistance Guided Therapy (RGT) for gonorrhoea may reduce unnecessary use of broad spectrum antibiotics.
From the lab to the clinic: Finding your feet with molecular resistance testing
Drs Winter and Moss share practical learning from their experience of introducing molecular resistance testing for gonorrhoea into a large urban population. They discuss implementation considerations and describe how these systems helped influence treatment decisions. Including examples where molecular resistance testing made a difference in patient management.
Please contact SpeeDx for information about offering SpeeDx diagnostics in your clinic or for a list of current pathology clinics where SpeeDx testing is available.
|ResistancePlus® GC*||LC480 II†||100 reactions||2011001|
|ABI 7500 / ABI 7500 Fast /
ABI 7500 Fast Dx҂
|CFX96 IVD/CFX96 Touch#||100 reactions||2015001|
|ResistancePlus® GC Analysis Software*||LC480 II||1 unit||99010|
|ABI 7500 / ABI 7500 Fast /
ABI 7500 Fast Dx
|CFX96 IVD/CFX96 Touch||1 unit||99015|
|PlexPCR® Colour Compensation*^ kit||LC480 II||2 reactions||90001|
|ResistancePlus® GC Control* kit||All platforms||10 reactions||95003|
*Not for sale in USA
†Validated on LightCycler 480 II
҂Validated on ABI 7500 Fast and ABI 7500 Fast Dx
#Validated on CFX96 IVD and CFX96 Touch
^Supplied upon request. This kit is only required for initial set-up to establish calibration of PlexPCR® and ResistancePlus® kits on the LC480 instrument, see instruction for use for details.