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      Resistance Guided Therapy

      SpeeDx ResistancePlus® diagnostics detect the infecting organism and antibiotic susceptibility or resistance markers – empowering clinicians to make informed patient treatment decisions.

      What is Resistance Guided Therapy?

      Resistance Guided Therapy (RGT) uses advances in diagnostic technology to help clinicians choose the best targeted therapy for individual patients based on the resistance status of their infection.

      • RGT uses tests that detect the infecting organism and genetic markers linked to antibiotic susceptibility or infection
      • RGT can replace empiric treatment models by providing additional information at the time of diagnosis to guide appropriate treatment decisions

      Why is Resistance Guided Therapy important?

      Strategies for controlling many STIs are dependent on the availability of inexpensive yet highly effective antibiotics. As antimicrobial resistance rates rise in these infections it even more important to use our limited antibiotics more wisely.

      Guidelines for management of STIs caused by Mycoplasma genitalium and Neisseria gonorrhoeae increasingly recommend RGT to help:

      • improve likelihood of effective patient treatment
      • reduce re-admission and healthcare costs
      • minimise the spread of antibiotic resistant infections
      • maintain the efficacy of antibiotic treatment (antibiotic stewardship)

      Declining cure rates when employing detection-only practices for M. genitalium addressed with implementation of RGT, increasing cure rates for macrolide susceptible populations to 95% and total population cure rate over 92%.1

      Resistance Guided Therapy

      Improve cure rate and simplify patient management.

      40%

      Cure rate of Mgen without RGT1

      95%

      Cure rate of Mgen with RGT1

      100%

      GC-infected patients receiving injection without RGT2-5

      30%

      GC-infected patients receiving injection with RGT2-5

      Implement RGT in your Laboratory

      ResistancePlus® tests give your laboratory a competitive advantage. Now you can offer your clinicians more than just detection. The combination of resistance data with infection detection in a single-well test, enables RGT for improved patient management.

      Products

      ResistancePlus® tests combine organism detection with genetic markers linked to antibiotic susceptibility or resistance. PlexPCR® tests combine multiple, clinically relevant infectious disease targets into a single test solution.

      Sexually Transmitted Infections

      ResistancePlus® GC

      Single well qPCR test detecting Neisseria gonorrhoeae and markers linked to ciprofloxacin susceptibility

      PlexPCR® VHS

      Single well qPCR test detecting and differentiating HSV-1, HSV-2, VZV & Treponema pallidum (Syphilis)

      ResistancePlus® MG

      Single well qPCR test detecting Mycoplasma genitalium and markers linked to macrolide resistance

      PlexPCR® HSV-1&2, VZV

      Single well qPCR test detecting and differentiating HSV-1, HSV-2 and VZV

      Respiratory

      GeneXpert®

      PlexPCR® RespiVirus

      2 well qPCR test detecting and differentiating 11 respiratory viruses

      ResistancePlus® MG FleXible

      Cartridge-based test detecting M. genitalium and macrolide resistance markers

      Products

      ResistancePlus® tests combine organism detection with genetic markers linked to antibiotic susceptibility or resistance. PlexPCR® tests combine multiple, clinically relevant infectious disease targets into a single test solution.

      Sexually Transmitted Infections

      ResistancePlus® GC

      Single well qPCR test detecting Neisseria gonorrhoeae and markers linked to ciprofloxacin susceptibility

      PlexPCR® VHS

      Single well qPCR test detecting and differentiating HSV-1, HSV-2, VZV & Treponema pallidum (Syphilis)

      ResistancePlus® MG

      Single well qPCR test detecting Mycoplasma genitalium and markers linked to macrolide resistance

      PlexPCR® HSV-1&2, VZV

      Single well qPCR test detecting and differentiating HSV-1, HSV-2 and VZV

      Respiratory

      PlexPCR® RespiVirus

      2 well qPCR test detecting and differentiating 11 respiratory viruses

      GeneXpert®

      ResistancePlus® MG FleXible

      Cartridge-based test detecting M. genitalium and macrolide resistance markers

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      References:
      1Read TRH et al. Clinical Infectious Diseases 2019; 68(4):554-560
      2Harris SR et al. Lancet Infect Dis Published online May 15th 2018
      3Lahra MM et al. Australian Gonococcal Surveillance Programme annual report, 2015
      4Heffernan H et al. Antimicrobial resistance and molecular epidemiology of gonococci in NZ, 2014-5
      5Kirkcaldy RD et al. MMWR Surveillance Summaries July 15, 2016 / 65(7);1–19